CBD, or cannabidiol, is one of the two most prominent molecules found in the cannabis plant and does not have any psychoactive properties. CBD is extracted from both marijuana and hemp, each having different makeups. Hemp derived CBD has very low THC levels, whereas CBD extracted from the marijuana plant can have higher levels of THC and have psychoactivity.
Like THC, CBD works on the cannabinoid receptors, located throughout the body from the brain to connective tissue. As part of the endocannabinoid system, the cannabinoid receptors are involved in regulation the balance of many everyday functions in the human body. There are two cannabinoid receptors of interest with CBD: Cannabinoid-receptor type 1 (CB1) and cannabinoid receptor type 2 (CB2).
Cannabinoid receptor type 1 is found in the central nervous system and are present in the peripheral tissues including the endocrine glands, spleen and heart.
Cannabinoid receptor type 2 are not found in the central nervous system. But together CB1 and CB2 are responsible for regulating neuro-hormones in the body and can affect mood, memory, sensations of pain and appetite regulation. This explains the wide range of potential treatment options for CBD.
Under the passage of the 2018 farm bill in December 2018, CBD was a controlled substance under federal law. The passage of the bill allowed hemp to be designated an agricultural crop with a warning that the breakdown of the cannabinoid profile be listed on the label.
Although CBD (Cannabidiol) is a non-addictive cannabis compound with therapeutic attributes, CBD-drug interactions can be very problematic.
Cannabis, like all herbs, are polypharmaceutical substances, meaning they have the potential to interact with medications, other herbs and over-the-counter items. The interactions can range from an increase in uncomfortable symptoms to life-threatening. Its critical to understand the effects CBD has on medications so you can make an informed decision.
Our liver has specialized enzymes called Cytochrome P450 that have the function of breaking down drugs into smaller items called metabolites. In this small form our cells can better absorb the drug and then eliminate them properly. Cytochrome P450 is responsible for the breakdown of 90% of the drugs on the market today (over-the-counter and prescription). This includes Benzodiazepines, Sleeping Pills, Antidepressants, Muscle Relaxers, Painkillers, blood pressure medications, etc. Adding CBD to your medication regimen means there is a high probability that CBD will alter how your drugs are both metabolized and then eliminated. Toxicity can occur because the ability to release the drug metabolites are hindered by CBD.
The metabolization of medications, herbs, CBD and over-the-counter can also vary. Many people are Poor Metabolizers, meaning they have less than normal Cytochrome P450 enzymes and therefore breakdown medications very slowly. Interactions for Poor Metabolizers can be extremely troublesome and dangerous.
The rule of thumb is that while taking any medications its best to avoid any item that travels Cytochrome P450, including CBD.
The nutraceuticals utilized at Point of Return do not travel Cytochrome P450 and therefore will not interact with any medications yet can provide the needed relief many are seeking.
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*You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, before reducing any medication or if you have or suspect you might have a health problem. Never abruptly stop anything, but rather speak to your healthcare practitioner and pharmacist. You should consult with your medical professional to determine if any interaction item needs to be tapered.
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