Clonazepam, like all benzodiazepines, has a high risk of dependence, and due to its rapid onset and long half-life it can cause significant alterations to the GABAa receptors.  Clonazepam slows respiratory function and heart rate which can potentially cause a deadly overdose when combined with other central nervous system agents such as painkillers. Do not abruptly stop taking Clonazepam, it must be tapered slowly. In addition to helping with Clonazepam withdrawal symptoms, a slow Clonazepam taper gives time to help repair the alterations to the GABA receptors. GABA is the great calming neurotransmitter of the human body and we have found that calming the nervous system during the taper and after provides the best chance for success. Recovery is possible. Let us help guide you with our In-Home Withdrawal Program.*
Below is information about Clonazepam, Clonazepam withdrawal symptoms, Clonazepam taper, and getting off Clonazepam naturally.
SIGNS OF CLONAZEPAM DEPENDENCY
Dependence to Clonazepam can occur rapidly, within after only a few days of continuous use. Even small regular doses of Clonazepam can cause dependence and Clonazepam Dependence can occur even if you are taking Clonazepam exactly as prescribed. The initial signs of dependency are anxiety between dosages, an erosion of sleep patterns and the knowledge that you cannot sleep unless you take your Clonazepam. Muscle weakness, an increase in pain, confusion, difficulty breath, racing thoughts, a sense of depersonalization and an uncomfortable internal agitation are all signs your body has adapted to Clonazepam and its time to consider tapering Clonazepam slowly.* 
WHAT IS CLONAZEPAM WITHDRAWAL LIKE?
Even missing one dose of Clonazepam can trigger severe panic, shortness of breath and an increase in blood pressure. While some are able to easily stop Clonazepam, many find the Clonazepam Withdrawal Symptoms crippling that include extreme panic, racing thoughts, an inability to sleep, loss of appetite, extreme emotions, tinnitus and sensitivity to light and sound.  Clonazepam Withdrawal, like all benzodiazepines, are deemed the most challenging withdrawal syndrome and why its essential to taper Clonazepam slowly.*
Clonazepam Withdrawal Help - Getting off Naturally
Our Clonazepam In-Home weaning program is a slow Clonazepam taper that allows you to step down from Clonazepam under the guidance of Our Team, Your Physician and Pharmacist. The Pre-Taper is for Symptom Relief. You will not wean Clonazepam until you feel better. This is where our Advanced Nutraceuticals are critical. Point of Return provides healthy, Drug-Free Strategies to help ease Clonazepam withdrawal symptoms and support well-being.*
Our areas of expertise are Antidepressants, Benzodiazepines, Sleeping Pills and Painkillers on a case-by-case basis. Our In-Home programs are individualized based on your situation. An assessment is done once you start the Clonazepam Withdrawal Program which allows us to individualize your gameplan based on age; length of time on the medications; health challenges; lifestyle, stress levels; additional medications; goals; and interactions. Don't Wean Clonazepam alone, work with our Prescription Drug Experts.*
CLONAZEPAM WITHDRAWAL SYMPTOMS MAY INCLUDE
- balance issues
- blurred vision
- brain zaps
- concentration impairment
- crying spells
- electric shock sensations
- flu-like symptoms
- highly emotional
- impaired speech
- jumpy nerves
- lack of coordination
- migraine headaches / increased headaches
- over-reacting to situations
- repetitive thoughts or songs
- sensory & sleep disturbances
- severe internal restlessness (akathisia)
- stomach cramps
- tremors, tinnitus (ear ringing or buzzing)
- tingling sensations
- troubling thoughts
- visual hallucinations / illusions
- vivid dreams
- speech or visual changes
- worsened depression
- abdominal and muscle cramps
- feeling of discomfort
- inability to fall asleep or stay asleep
IMAGINE BEING FREE OF CLONAZEPAM DEPENDENCY
✔ Proven Program completed In-Home with Expert Guidance
✔ Slowly Taper Clonazepam
✔ All-Natural Nutraceuticals to help Ease Clonazepam Withdrawal Symptoms*
✔ Your program is customized for your specific situation
✔ Professional information on interactions
✔ Free Mentoring on our 24/7 private Discussion Board
✔ Free Assessment Upon Starting our Program (a $400 value)
Enter Discount Code BenzoFree for FREE Ground Shipping on your Withdrawal Program (USA & Canada Only)
CLONAZEPAM WITHDRAWAL TIMELINE
While Clonazepam withdrawal symptoms can occur after missing one dose, the full onset of Clonazepam withdrawal typically begins within 3-4 days after the last dose.  The duration of Clonazepam withdrawal symptoms can vary tremendously depending on age, health challenges, length of time on Clonazepam, and other medications.*
Clonazepam causes both severe physical withdrawal symptoms and also psychological alterations that include an increase in fear, panic, agitation, irrational thoughts, muscle spams, pain, an increase in blood pressure and heart rate, seizures (if stopped abruptly), weakness, severe insomnia and tremors.* 
A gradual taper off Clonazepam minimizes the severity of Clonazepam Withdrawal, yet many find the symptoms continue to interfere with all aspects of life. If you need help to taper off Clonazepam, this can increase your chance of success in breaking the dependency to Clonazepam. We know various approaches to help make Clonazepam withdrawal more manageable.*
CLONAZEPAM WITHDRAWAL SUCCESS STORIES
I know this will sound corny but I do thank you from the bottom of my heart. Thank you, thank you and I thank the entire Point of Return staff. You are a remarkable group of people. More...
Heloise (Clonazepam Withdrawal Success Story)
I simply cannot recommend Point of Return highly enough for people whose bodies have become dependent on medication(s)…They know, they understand, and they are there to help you. More...
Joel (Clonazepam Withdrawal Success Story)
Point Of Return has given me my life back! I would hate to know where I'd be without Point of Return. If you or a loved one need help in this area, please contact them. More...
Christina (Clonazepam Withdrawal Success Story)
Mary (Clonazepam Withdrawal Success Story)
Hardly a day goes by when I don't ask myself "where would I be today without Point of Return!" More...
CLONAZEPAM SIDE EFFECTS AND ADVERSE REACTIONS
CLONAZEPAM SIDE EFFECTS MAY INCLUDE:
Daytime drowsiness, amnesia or forgetfulness, memory impairment, muscle weakness, lack of balance or coordination, cognitive issues, tiredness, changes in appetite, nausea, diarrhea ,stomach upset, headache, muscle pain, confusion, insomnia, visual changes, memory loss, difficulty concentrating, confusion, hallucinations, slurred speech, agitation, aggressive behavior, anxiety, loss interest in sex, fatigue, nervousness, worsening depression
CLONAZEPAM ADVERSE REACTIONS MAY INCLUDE: per PDR
Severe: suicidal ideation, coma, teratogenesis, visual impairment
Moderate: ataxia, depresion, memory impairment, constipation, dysarthria, vaginitis, impotence, blurred vision, confusion, migraine, paresis, excitability, hemorrhoids, candidiasis, dyspnea, urinary incontinence, dysuria, urinary retention, bleeding, cystitis, hypertonia, contact dermatitis, orthostatic hypotension, edema, chest pain, palpitations, gout, tolerance, physiological dependence,
amnesia, hallucinations, hostility, psychosis, fecal incontinence, gastritis, withdrawal, respiratory depression, lymphadenopathy, hypotonia, nystagmus, thombocytopenia, anemia, eosinophilia, elevated hepatic enzymes, leukopenia, hepatomegaly, dehydration
Mild: drowsiness, dizziness, infection, fatigue, sinusitis, dysmenorrhea, influenza, rhinitis, cough, myalgia, anorexia, pharyngitis, libido decrease, emotional lability, abdominal pain, increased urinary frequency, vertigo, hypoesthesia, tremor, paresthesias, shivering, anxiety, insomnia, nightmares, yawning, dyspepsia, weight gain, flatulence, dysgeusia, pyrosis, weight loss, appetite stimulation, hyper salivation, fever, epistaxis, hoarseness, sneezing, libido increase, menstrual irregularity, urine discoloration, polyuria, back pain, musculoskeletal pain, muscle cramps, arthralgia, diplopia, xerophthalmia, alopecia, flushing, pruritus, acne vulgaris, headache, agitation, irritability, nausea, diarrhea, rhinorrhea, nocturia, weakness, rash, hirsutism
CLONAZEPAM TECHNICAL DATA AND REFERENCES
Clonazepam, like all Benzodiazepines, are anxiolytics that have amnesia-inducing and hypnotic effects, but are generally prescribed for sleep latency and anxiety disorders. Like alcohol, Clonazepam increase the efficiency of synaptic transmission of the neurotransmitter GABAa by acting on its receptors.
A GABA receptor is a macromolecular complex that, in addition to containing sites for binding GABA, also contain sites for binding other molecules such as benzodiazepines that modulate GABA's activity. When Clonazepam or any benzodiazepine binds to a specific site on a GABA receptor, they do not stimulate it directly, but rather make it more efficient by increasing the frequency with which the chlorine channel opens when GABA binds to its own site on this receptor. The resulting increase in the concentration of CI-ions (chorine anion) in the post synaptic neuron immediately hyperpolarizes this neuron, making it less excitable.
Clonazepam is a long-acting and high potency benzodiazepine that behaves both as a GABA-A receptor agonist. Clonazepam also has Serotonergic activity by increasing serotonin synthesis.  Clonazepam has anticonvulsant and anxiolytic effects. It is FDA-approved for the treatment of seizure and panic disorders.   It also has off label use as monotherapy or adjunctive therapy for the treatment of mania, restless leg syndrome, insomnia, tardive dyskinesia, and REM sleep behavior disorder.   
Clonazepam is highly potent and a long-acting benzodiazepine. It exerts its pharmacological effects by acting as a positive allosteric modulator on GABA-A receptors. The GABA-A receptor is a ligand-gated chloride ion-selective channel whose endogenous ligand is GABA (gamma-aminobutyric acid). Benzodiazepines (BZDs) facilitate GABA-A action by increasing the frequency of chloride channel opening resulting in hyperpolarization of the neurons and decreased firing, thus producing calming effects on the brain by reducing the excitability of the neurons.
GABA is an inhibitory neurotransmitter that is present in abundance in the cortex and limbic system. There are three types of GABA receptors A, B, and C. However, BZDs act only on GABA-A receptors. Each receptor complex has 2 GABA-binding sites and 1 BZD-binding site and is made of five subunits two alpha, two beta, and one gamma. BZDs do not bind to the same receptor site on the receptor complex as the endogenous ligand GABA but bind to distinct BZD-binding sites situated at the interface between the alpha and gamma subunits. The binding results in a conformational change in the GABA-A receptor's chloride channel that results in the hyperpolarization of the cell and accounts for GABA's inhibitory effect throughout the central nervous system. 
GABA receptors also classify into various BZDs receptors based on the isoforms of the alpha subunit. The benzodiazepine type-1 receptors (BZ1), which contain alpha-1 subunits, are present in abundance in the cortex, thalamus, and cerebellum are responsible for their anticonvulsant and sedative effects. Whereas benzodiazepine type-2 receptors containing alpha-2 subunits, mostly concentrated in the limbic system, motor neurons and dorsal horn of spinal cord, mediate the anxiolytic effects of BZDs.
NEONATAL CLONAZEPAM ADMINISTRATION
An October 11, 2018 study by the Institute of Physiology, Academy of Sciences of the Czech republic, Prague, Czechia, suggests that relatively short exposure to CZP during early postnatal stages of development results in substantial expression changes in NMDA and AMPA receptor subunit mRNAs and [3H]-MK-801 binding, both shortly after treatment cessation and over the long term. How these changes affect synaptic plasticity and their impact on these early changes in development of neuronal networks warrants further investigation. We suggest that the changes described in this study may be involved in the development of withdrawal signs after BZD cessation in the immature brain. Together with increased apoptosis (Ikonomidou et al., 2001; Bittgau et al., 2002; Jevotivic-Todorovic et al., 2003) and suppressed neurogenesis (Chen et al., 2009) previously described in immature animals exposed to BZDs, changes in the glutamatergic system participate in behavioral alterations observed later in life.
Clonazepam is available as a tablet may be administered once at bedtime to minimize somnolence. The patient should take the drug with water by swallowing the whole tablet and must be immediately used after removing from package. Clonazepam has rapid absorption after oral administration. The maximum plasma concentration is reached within one to four hours after oral administration, and it is approximately 85% bound to plasma proteins. Clonazepam is highly metabolized by the liver's cytochrome P-450 in particular by CYP3A in a dose-dependent manner. The elimination half-life of clonazepam is around 30 to 40 hours.
ACCORDING TO THE FDA:
Withdrawal Symptoms: Withdrawal symptoms of the barbiturate type have occurred after the discontinuation of benzodiazepines (see DRUG ABUSE AND DEPENDENCE).
General: Worsening of Seizures: When used in patients in whom several different types of seizure disorders coexist, Klonopin may increase the incidence or precipitate the onset of generalized tonic-clonic seizures (grand mal). This may require the addition of appropriate anticonvulsants or an increase in their dosages. The concomitant use of valproic acid and Klonopin may produce absence status. Laboratory Testing During Long-Term Therapy: Periodic blood counts and liver function tests are advisable during long-term therapy with Klonopin.
Risks of Abrupt Withdrawal: The abrupt withdrawal of Klonopin, particularly in those patients on long-term, high-dose therapy, may precipitate status epilepticus. Therefore, when discontinuing Klonopin, gradual withdrawal is essential. While Klonopin is being gradually withdrawn, the simultaneous substitution of another anticonvulsant may be indicated.
CLONAZEPAM BOXED WARNINGS: per PDR
Asthma, bronchitis, chronic obstructive pulmonary disease (COPD), CNS depression, coadministration with other CNS depressants, coma, pulmonary disease, respiratory depression, shock, sleep apnea
As with other benzodiazepines, clonazepam should be used with extreme caution in patients with pulmonary disease or conditions associated with compromised respiratory function such as sleep apnea  , bronchitis, pneumonia, asthma, or chronic obstructive pulmonary disease (COPD). Additionally, avoid coadministration with other CNS depressants, especially opioids, unless no other alternatives are available as coadministration significantly increases the risk for respiratory depression, low blood pressure, and death. If coadministration is necessary, follow patients for signs and symptoms of respiratory depression and sedation. Clonazepam should not be used in patients with preexisting respiratory depression, cases of shock, or coma because the drug can worsen respiratory and CNS depression. In patients who snore regularly, partial airway obstruction may convert to obstructive sleep apnea with benzodiazepine administration. Clonazepam may produce hypersalivation and may aggravate conditions in which patients have difficulty handling secretions.*
 Chouinard G,Labonte A,Fontaine R,Annable L, New concepts in benzodiazepine therapy: rebound anxiety and new indications for the more potent benzodiazepines. Progress in neuro-psychopharmacology [PubMed PMID: 6141609]
*While great care has been taken in organizing and presenting the material throughout this website, please note that it is provided for informational purposes only and should not be taken as Medical Advice.
*The statements/info on this website have not been evaluated by the Food and Drug Administration (FDA). The products and labels mentioned / sold are not intended to diagnose, treat, cure, or prevent any disease or illness.
*The program outlined in Point of Return is not meant to substitute your doctor, instead it is to be utilized with Your physician to help you with your drug withdrawal process and with his or her consent throughout.
*This program is not meant to cure or prevent any disease or illness.
*Because prescription medications can cause severe withdrawal reactions, do not stop taking any medication without first consulting your physician. The decision to taper any medication should be discussed with your doctor and done with their consent and support throughout the process. More..