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Klonopin Withdrawal Help
Getting off Klonopin Naturally


Klonopin can degrade the immune system in distinct ways and studies have shown that immune deficiencies were caused by Klonopin. There has never been a more critical time for getting off Klonopin naturally while supporting your immune system. Have you tried to Stop Taking Klonopin with poor results? Do you want to learn how to taper off Klonopin successfully? Klonopin Withdrawal can be difficult, but our nonprofit has successfully helped people in 78 countries to get off Klonopin naturally and we can help you.

Below is information about Klonopin, Klonopin withdrawal, and getting off Klonopin naturally.


Table of Contents

 

WHAT IS KLONOPIN?

 

Klonopin enhances the neurotransmitter GABA, which is the most common inhibitory, or calming neurotransmitter. Therefore Klonopin has a profound effect on nearly every aspect of the body and brain. As tolerance to the drug occurs, the calming effect diminishes and breakthrough anxiety and extreme excitability occurs. Many misinterpret tolerance for a worsening of anxiety and increase the dosage, only to reach tolerance again. Chronic use of Klonopin, like all benzodiazepines, causes a down regulation of GABA. It is this action that is responsible for the widespread withdrawal symptoms.  Tolerance to Klonopin's anticonvulsant effect occurs frequently and chronic use leads to tolerance for the anti-anxiety properties. One milligram of Klonopin is approximately equivalent to twenty milligrams of Diazepam (Valium), making Klonopin a 'highly potent' benzodiazepine. Abrupt withdrawal of Klonopin can cause seizures, severe withdrawal symptoms and be life-threatening. A gradual dose reduction is recommended. Klonopin (Clonazepam) was brought to market in 1975 for the treatment of epilepsy. Dr. Leo Sternbach, an award winning chemist, helped the Swiss drug conglomerate Roche Pharmaceutical build its U.S. division, after fleeing Europe when the Nazis were threatening to invade Europe in 1941. 

Sternbach went on to patent 241 drugs, including Valium, and accounted for 40% of Roche's worldwide sales. The use of Klonopin expanded beyond epilepsy and was used for anxiety, insomnia, muscle tension and many other ailments.   

The prescribing of benzodiazepines has increased dramatically in the U.S. military with tens of thousands of soldiers returning from combat with anxiety. Unfortunately this trend has caused high rates of benzodiazepine addiction. While the U.S. Government is slow to recognize the dangers, the Lavarack Barracks, a major Australian base in Queensland, Australia has a zero tolerance policy for illegal and prescription drugs and recently dismissed soldiers for using benzodiazepines since they are not prescribed in the Australian military.   

According to the U.S. Center for Disease Control, all benzodiazepines, including Klonopin, do not mix well with narcotic painkillers and can cause breathing difficulties that can be fatal.  top of page

Please let the Point of Return program work for you. It is a slow, gentle reduction from drugs, and will provide you with the tools you need to succeed.”

—Liz (Klonopin)


KLONOPIN SIDE EFFECTS/SYMPTOMS

 

KLONOPIN SIDE EFFECTS MAY INCLUDE: 

Daytime drowsiness, amnesia or forgetfulness, memory impairment, muscle weakness, lack of balance or coordination, cognitive issues, tiredness, changes in appetite, nausea, diarrhea ,stomach upset, headache, muscle pain, confusion, insomnia, visual changes, memory loss, difficulty concentrating, confusion, hallucinations, slurred speech, agitation, aggressive behavior, anxiety, loss interest in sex, fatigue, nervousness, worsening depression

KLONOPIN ADVERSE REACTIONS MAY INCLUDE: per PDR 

Severe: suicidal ideation, coma, teratogenesis, visual impairment 

Moderate: ataxia, depresion, memory impairment, constipation, dysarthria, vaginitis, impotence, blurred vision, confusion, migraine, paresis, excitability, hemorrhoids, candidiasis, dyspnea, urinary incontinence, dysuria, urinary retention, bleeding, cystitis, hypertonia, contact dermatitis, orthostatic hypotension, edema, chest pain, palpitations, gout, tolerance, physiological 

dependence, psychological dependence, amnesia, hallucinations, hostility, psychosis, fecal incontinence, gastritis, withdrawal, respiratory depression, lymphadenopathy, hypotonia, nystagmus, thombocytopenia, anemia, eosinophilia, elevated hepatic enzymes, leukopenia, hepatomegaly, dehydration 

KLONOPIN ADVERSE REACTIONS MAY INCLUDE: per PDR  continued  

Mild: drowsiness, dizziness, infection, fatigue, sinusitis, dysmenorrhea, influenza, rhinitis, cough, myalgia, anorexia, pharyngitis, libido decrease, emotional lability, abdominal pain, increased urinary frequency, vertigo, hypoesthesia, tremor, paresthesias, shivering, anxiety, insomnia, nightmares, yawning, dyspepsia, weight gain, flatulence, dysgeusia, pyrosis, weight loss, appetite stimulation, hyper salivation, fever, epistaxis, hoarseness, sneezing, libido increase, menstrual irregularity, urine discoloration, polyuria, back pain, musculoskeletal pain, muscle cramps, arthralgia, diplopia, xerophthalmia, alopecia, flushing, pruritus, acne vulgaris, headache, agitation, irritability, nausea, diarrhea, rhinorrhea, nocturia, weakness, rash, hirsutism  

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SIGNS OF KLONOPIN ABUSE 

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WHAT IS KLONOPIN WITHDRAWAL LIKE? 

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Klonopin Withdrawal Symptoms

Aggression, anxiety, balance issues , blurred vision, brain zaps, concentration impairment, constipation, crying spells, depersonalization, diarrhea, dizziness. electric shock sensations, fatigue, flatulence, flu-like symptoms, hallucinations, hostility, highly emotional, indigestion, irritability, impaired speech, insomnia, jumpy nerves, lack of coordination, lethargy, migraine headaches / increased headaches, nausea, nervousness, over-reacting to situations, paranoia, repetitive thoughts or songs, sensory & sleep disturbances, severe internal restlessness (akathisia), stomach cramps, tremors, tinnitus (ear ringing or buzzing), tingling sensations, troubling thoughts, visual hallucinations / illusions, vivid dreams, speech or visual changes, worsened depression, insomnia, abdominal and muscle cramps, convulsions, feeling of discomfort, inability to fall asleep or stay asleep, sweating, tremors, vomiting.

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Klonopin Withdrawal Help - How It Works


Our Klonopin weaning program is a slow taper that allows you to step down from Klonopin under the guidance of Our Team, Your Physician and Pharmacist. The Pre-Taper is for Symptom Relief. You will not wean Klonopin until you feel better. This is where our Advanced Nutraceuticals are critical. Point of Return provides healthy, Drug-Free Strategies to help ease Klonopin withdrawal and support well-being.*

Our areas of expertise are Antidepressants, Benzodiazepines, Sleeping Pills and Painkillers on a case-by-case basis. Our In-Home programs are individualized based on your situation. An assessment is done once you start the Klonopin Withdrawal Program which allows us to individualize your gameplan based on age; length of time on the medications; health challenges; lifestyle, stress levels; additional medications; goals; and interactions. Don't Wean Klonopin alone, work with our Prescription Drug Experts.*


Klonopin Withdrawal Timeline

The Klonopin withdrawal duration can vary from person to person and there are risks with withdrawing too quickly. Risks of Abrupt Withdrawal: The abrupt withdrawal of Klonopin, particularly in those patients on long-term, high-dose therapy, may precipitate status epilepticus. Therefore, when discontinuing Klonopin, gradual withdrawal is essential. While Klonopin is being gradually withdrawn, the simultaneous substitution of another anticonvulsant may be indicated.

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KLONOPIN WITHDRAWAL SUCCESS STORIES

Christina - Klonopin Withdrawal Success Stories

Please TRUST Point of Return.  Trust their personnel.  They DO understand, and their programme and products work! More...

Carolyn (Klonopin)

Joel - how to taper off Klonopin

I simply cannot recommend Point of Return highly enough for people whose bodies have become dependent on medication(s)…They know, they understand, and they are there to help you. More...

Joel (Klonopin)

Christina - Klonopin Withdrawal Success

Point Of Return has given me my life back! I would hate to know where I'd be without Point of Return. If you or a loved one need help in this area, please contact them. More...

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Suzanne - how to taper off Klonopin

"The return of joy in my home and happiness on the faces of my children make me confident that you, too, will find hope at Point of Return."  More...

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Paul - Klonopin Withdrawal Success

"If you feel trapped by pharmaceuticals like SSRI's and Benzos, please know there is hope.  I am now free of the grip of Ativan and Klonopin. The Point of Return nutraceuticals and star are the key to reclaiming your life.  You can do this, I know because I've been there!" More...

Paul (Klonopin)
Helen Klonopin Withdrawal Success Stories

"If you are frightened because of the nightmare of prescription drug dependence, please done despair. If you are dedicated to getting well, and put in the time and effort, they will support you every step of the way." More...

Helen (Klonopin)

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KLONOPIN WITHDRAWAL SYMPTOMS, SIDE EFFECTS AND ADVERSE REACTIONS ( link | pdf ) 
KLONOPIN HISTORY AND INFO  ( link | pdf
KLONOPIN TECHNICAL DATA AND REFERENCES ( link | pdf )
KLONOPIN WITHDRAWAL HELP (link)

    KLONOPIN TECHNICAL DATA AND REFERENCES

     

    INTRODUCTION TO BENZODIAZEPINES PHARMACODYNAMICS:

    Benzodiazepines are one of the most widely prescribed pharmacologic agents in the United States (more than 112 million prescriptions in 2007).[1]

    Klonopin and all Benzodiazepines are used for numerous indications, including anxiety, insomnia, muscle relaxation, relief from spasticity caused by central nervous system pathology, and epilepsy. Benzodiazepines are also used intraoperatively because of their amnesic and anxiolytic properties. However, these properties become undesired side effects in nearly all other clinical instances.

    The severity of Benzodiazepine-induced adverse effects forces physicians to exercise caution and pay attention to side effects when prescribing this class of agents. Tolerance, dependence, age-related physiological changes, and drug-drug interactions are all important considerations and why Klonopin and all Benzodiazepines should only be prescribed for short term use. This review explains the mechanisms of action of Benzodiazepines, compares and contrasts popular Benzodiazepines on the market today, and describes specific Benzodiazepine-mediated effects and side effects.[2q]

    Another way to characterize Benzodiazepines is by relative potency. The first Benzodiazepines were low to medium potency. These include long-acting chlordiazepoxide, the first Benzodiazepine discovered, as well as oxazepam and temazepam. Because of their effectiveness and relatively low toxicity, they became first-line agents for conditions such as insomnia and anxiety. Later, high-potency Benzodiazepines (alprazolam, lorazepam, and clonazepam (Klonopin) were discovered.

    These new drugs led to new indications for usage: as a treatment for panic disorders,[3] as adjuncts to selective serotonin reuptake inhibitors for treatment of obsessive-compulsive disorder, and as adjuncts to antipsychotics for treatment of acute mania or agitation.[11] The newer high-potency Benzodiazepines showed improved therapeutic effects as well as faster onset of action, making them the preferred Benzodiazepines for most applications. However, with increased potency comes an increase in the risk of undesired effects. Therefore, when prescribing drugs in this Benzodiazepine group, clinicians must consider individual properties such as absorption, distribution, elimination half-life, and lipid solubility.

    KLONOPIN (Clonazepam)

    Klonopin was the second high-potency Benzodiazepine discovered. Klonopin behaves both as a GABA-A receptor agonist in a highly-potent, long-acting manner and also as a serotonin agonist.[4] Klonopin has anticonvulsant and anxiolytic effects. One study proved Klonopin to be at least as effective as lithium for treating acute mania.[4] In association with serotonin reuptake blockers, Klonopin appears to accelerate treatment response to panic disorder.[4] In another study, Klonopin proved as effective for treating panic disorders as alprazolam, and termination did not cause rebound anxiety symptoms[5] because of Klonopin's long elimination half-life. Because Klonopin displays low lipid solubility, it is less likely to cause anterograde amnesia compared to the other high-potency BZDs. For example, Klonopin is half as lipid soluble as alprazolam, so patients' amnesic side effects are reduced. Klonopin also has a relatively weaker binding affinity for GABA-A receptors than the other high-potency BZDs.[4] Klonopin, when used to treat panic disorders, should be initiated at a dose of 0.25 mg tablets, taken orally twice a day for 3 days, after which the dose should be increased to 0.5 mg tablets twice daily. The maximum daily dose should not exceed 1-4 mg. For treating seizure disorders, adults should start with 0.5 mg tablets taken orally 3 times per day. For this indication, the maximum daily dose should not exceed 20 mg. In the pediatric population, beginning with a dose of 0.01-0.03 mg/kg orally divided into 2 or 3 doses is recommended. The maximum dose in this population should not exceed 0.1-0.2 mg/kg in 3 doses.

    Klonopin, like all Benzodiazepines, act as positive allosteric modulators on the gamma amino butyric acid (GABA)-A receptor. The GABA-A receptor is a ligand-gated chloride-selective ion channel.

    GABA is the most common neurotransmitter in the central nervous system, found in high concentrations in the limbic system and cortex. GABA is inhibitory in nature and thus reduces the excitability of neurons, and counters the stimulating Norepinephrine. GABA produces a calming effect on the brain and nervous system.[2] The 3 GABA receptors are designated A, B, and C. This article focuses primarily on the GABA-A receptor, with which Benzodiazepines, including Klonopin, interact.

    The GABA-A receptor complex is composed of 5 glycoprotein subunits, each with multiple isoforms. GABA-A receptors contain 2 α subunits, 2 β subunits, and 1 γ subunit and each receptor complex has 2 GABA-binding sites but only 1 Benzodiazepine-binding site. The benzodiazepine binding site is in a specific pocket at the pairing (intersection) of the α and γ subunits. Within the α subunit of isoforms 1, 2, 3, and 5 resides a histidine residue (H101, H101, H126, and H105, respectively) that possesses a high affinity for Klonopin (all Benzodiazepines).[3] Isoforms 4 and 6 of the α subunit contain an arginine residue and do not have an affinity for BZDs.[3]  BZDs bind to the pocket created by the α and γ subunits and induce a conformational change in the GABA-A receptor, allowing GABA to bind. BZDs bind to the pocket created by α and γ subunits and induce a conformational change in the GABA-A receptor. This alteration, in turn, induces a conformational change in the GABA-A receptor's chloride channel that hyperpolarizes the cell and accounts for GABA's inhibitory effect throughout the central nervous system. [3]

    ACCORDING TO THE FDA: 

    Withdrawal Symptoms: Withdrawal symptoms of the barbiturate type have occurred after the discontinuation of benzodiazepines (see DRUG ABUSE AND DEPENDENCE). 

    PRECAUTION

    General: Worsening of Seizures: When used in patients in whom several different types of seizure disorders coexist, Klonopin may increase the incidence or precipitate the onset of generalized tonic-clonic seizures (grand mal). This may require the addition of appropriate anticonvulsants or an increase in their dosages. The concomitant use of valproic acid and Klonopin may produce absence status. 

    Laboratory Testing During Long-Term Therapy: Periodic blood counts and liver function tests are advisable during long-term therapy with Klonopin. 

    Risks of Abrupt Withdrawal: The abrupt withdrawal of Klonopin, particularly in those patients on long-term, high-dose therapy, may precipitate status epilepticus. Therefore, when discontinuing Klonopin, gradual withdrawal is essential. While Klonopin is being gradually withdrawn, the simultaneous substitution of another anticonvulsant may be indicated. 

    KLONOPIN BOXED WARNINGS:  per PDR 

    Asthma, bronchitis, chronic obstructive pulmonary disease (COPD), CNS depression, coadministration with other CNS depressants, coma, pulmonary disease, respiratory depression, shock, sleep apnea  As with other benzodiazepines, clonazepam should be used with extreme caution in patients with pulmonary disease or conditions associated with compromised respiratory function such as sleep apnea, bronchitis, pneumonia, asthma, or chronic obstructive pulmonary disease (COPD). Additionally, avoid coadministration with other CNS depressants, especially opioids, unless no other alternatives are available as coadministration significantly increases the risk for respiratory depression, low blood pressure, and death. If coadministration is necessary, follow patients for signs and symptoms of respiratory depression and sedation. Clonazepam should not be used in patients with preexisting respiratory depression, cases of shock, or coma because the drug can worsen respiratory and CNS depression. In patients who snore regularly, partial airway obstruction may convert to obstructive sleep apnea with benzodiazepine administration. Clonazepam may produce hypersalivation and may aggravate conditions in which patients have difficulty handling secretions.

     REFERENCES:

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3684331/#i1524-5012-13-2-214-b12

    1.  Cascade E, Kalali AH. Use of benzodiazepines in the treatment of anxiety. Psychiatry (Edgmont) 2008 Sep;5(9):21–22. [PMC free article] [PubMed] [Google Scholar]

    2. Fox C, Liu H, Kaye AD.  Manchikanti L, Trescot AM, Christo PJ, et al, eds. Clinical Aspects of Pain Medicine and Interventional Pain Management: A Comprehensive Review.Paducah, KY: ASIP Publishing;; 2011. Antianxiety agents; pp. 543–552. In. [Google Scholar]

    3. Chouinard G, Annable L, Fontaine R, Solyom L. Alprazolam in the treatment of generalized anxiety and panic disorders: a double-blind placebo-controlled study. Psychopharmacology (Berl) 1982;77(3):229–233. [PubMed] [Google Scholar]

    4.  Chouinard G, Young SN, Annable L. Antimanic effect of  clonazepam. Biol Psychiatry. 1983 Apr;18(4):451–466.[PubMed] [Google Scholar]

    5.  Nardi AE, Perna G. clonazepam in the treatment of psychiatric disorders: an update. Int Clin Psychopharmacol. 2006 May;21(3):131–142. [PubMed] [Google Scholar]

    https://www.goodtherapy.org/blog/studies-show-klonopin-and-xanax-may-impair-immune-system-101612

    https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017533s053,020813s009lbl.pdf

    https://www.ncbi.nlm.nih.gov/pubmed/20473065

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934057/ 

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    DISCLAIMER:

    *While great care has been taken in organizing and presenting the material throughout this website, please note that it is provided for informational purposes only and should not be taken as Medical Advice.

    *The statements/info on this website have not been evaluated by the Food and Drug Administration (FDA). The products and labels mentioned / sold are not intended to diagnose, treat, cure, or prevent any disease or illness.

    * Testimonial results may vary person to person.

    *The program outlined in Point of Return is not meant to substitute your doctor, instead it is to be utilized With Your physician to help you with your drug withdrawal process and with his or her consent and support throughout.

    *This program is not meant to cure or prevent any disease or illness.

    *Because prescription medications can cause severe withdrawal reactions, do not stop taking any medication without first consulting your physician. The decision to taper any medication should be discussed with your doctor and done with their consent and support throughout the process. More..