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Phenibut was developed in the Soviet Union during the 1960s and has been used to treat anxiety, depression, insomnia and a wide range of conditions. Phenibut has proven to be highly addictive with side effects and withdrawals similar to Baclofen and Benzodiazepines. Tolerance can develop rapidly with Phenibut, necessitating a higher dose to obtain calming results.  Tapering slowly is always recommended.  Contact us f you need help tapering off Phenibut.

Phenibut is a central nervous system depressant that affects the GABA receptors.

GABA as a supplement cannot cross the blood/brain barrier, so Russian scientists added a phenyl ring to Phenibut and the result was that it worked on the GABA receptors in a similar way as baclofen or benzodiazepines. This explains the high rate of addiction and withdrawal symptoms from Phenibut.

In 2013 the European Monitoring Centre for Drugs and Drug Addiction added Phenibut to the list of psychoactive substances requiring attention.  Australia has listed Phenibut as a controlled substance although it is available as a supplement in the United States.

Phenibut was first made in St. Petersburg, Russia in 1963 as an experimental drug to treat psychiatric patients and by 1975 was widely used. It acts as a GABA-mimetic, primarily at GABA-B and, to some extent, at GABA-A receptors. It also stimulates dopamine receptors and antagonizes beta-phenethylamine. The psycho-pharmacological activity of Phenibut is similar to that of baclofen, a derivative of Phenibut, both are highly addictive with withdrawal symptoms similar to benzodiazepines.

Phenibut has a half-life of 5.3 hours and because withdrawal symptoms can be severe, it is critical to slowly taper to minimize withdrawal symptoms.  Need help to taper off Phenibut?

Call Point of Return

Withdrawal Symptoms May Include Candida:

  • Anxiety
  • Depression
  • Paranoia
  • Loss of Appetite
  • Rapid Heartbeat
  • Tremors
  • Hyperactivity/Hyperkinsesia
  • Insomnia
  • Aggression/Irritability
  • Cognitive deficits
  • Decreased pain threshold
  • Dizziness
  • Fatigue
  • Muscle tension
  • Nausea
  • Hallucinations
  • Nervousness

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