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Welcome to Point of Return

Pristiq Withdrawal and Tapering Help

Pristiq has higher rates of withdrawal symptoms (discontinuation syndrome) than other SNRI or SSRI antidepressants. Contact the Prescription Drug Experts for help! Our NonProfit has been helping people withdraw safely for over 15 Years.

Real Results for Pristiq Dependency

The Point of Return Program is an in-home tapering program that allows you to gradually lessen the amount of Pristiq while also implementing the use of all-natural, calming nutraceuticals to help ease symptoms. We eliminate Interaction items to help make Pristiq withdrawal more comfortable. Our physician recommended schedules allow your doctor to taper you off Pristiq correctly.  The success of our program over the past 14 years is due to our unmatched service and unique mentoring approach. Pristiq is dangerous to abruptly or rapidly stop and our program is a proven, viable, low-cost option to continue living your life while tapering.   Read program FAQs

We are experts that specialize in Antidepressant withdrawals.

Key Components of Our In-Home Program

  • Skilled Experts guiding you throughout the process
  • Assessment at the onset to determine a gameplan
  •  *Nutraceuticals specially formulated to help ease symptoms, these are utilized throughout the whole process  
  •   Unlike herbs and many vitamins, our nutraceuticals will not interact with any medications  
  •   24/7 discussion board with encouraging members and knowledgeable mentors
  •   Recommendations for addressing symptoms
  •   Experienced team of committed experts with over 15 years experience

Every person at Point of Return has a personal story with these drugs. You are never alone 

Call toll-free 866-605-2333 to Learn More or send us an Email.

We've helped people in 78 counties and in all 50 states in the USA


This is a low cost program with proven results

Here I am, at the other side.  I've returned to my life but it's better than it was before because I have such gratitude and appreciation for all that I have. more...

- Suzy L., (Canada) Pristiq, Temazepam

Withdrawal Symptoms May Include

aggression, anxiety, balance issues , blurred vision, brain zaps, concentration impairment, constipation, crying spells, depersonalization, diarrhea, dizziness. electric shock sensations, fatigue, flatulence, flu-like symptoms, hallucinations, hostility, highly emotional, indigestion, irritability, impaired speech, insomnia, jumpy nerves, lack of coordination, lethargy, migraine headaches / increased headaches, nausea, nervousness, over-reacting to situations, paranoia, repetitive thoughts or songs, sensory & sleep disturbances, severe internal restlessness (akathisia), stomach cramps, tremors, tinnitus (ear ringing or buzzing), tingling sensations, troubling thoughts, visual hallucinations / illusions, vivid dreams, speech or visual changes, worsened depression

Side Effects May Include

allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives), irregular heartbeat or pulse, low blood pressure (dizziness, weakness), high blood pressure (severe headache, blurred vision), chills or fever, unusual bleeding or bruising, rash or hives, Suicidal Ideation, Headache, tremor, nervousness, or anxiety; difficulty concentrating, constipation, nausea, diarrhea, dry mouth, or changes in appetite or weight, weakness, increased sweating, sleeping or insomnia, decreased sex drive, impotence, or difficulty having an orgasm

Other Names for Pristiq Include: 


Break Free Today

At Point of Return, a 501(c)3 nonprofit, we have spent the last 15 years helping people taper off antidepressants correctly. With customized taper rates and all natural nutraceuticals, our program allows you to come off Pristiq, once and for all, from the comfort of your home. Read program FAQs


" My heartfelt thanks to all of the POINT OF RETURN team – the group of participants that provide emotional support on the forum – and most of all – to Alesandra. - Kellia A. (Canada) more...

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Pristiq history and info

In relation to its parent substance, Venlafaxine, Pristiq seemed to be less effective with no advantages in terms of safety and tolerability." Wyeth subsequently withdrew its application for approval.

Pristiq has higher rates of withdrawal symptoms (discontinuation syndrome) than other SNRI or SSRI antidepressants. For some patients the symptoms can be severe and are considered intolerable. A gradual taper is recommended to minimize symptoms. Pristiq is the active metabolite of Venlafaxine and can have significant withdrawal symptoms.

Pristiq (Desvenlafaxine) is the active metabolite of Effexor (Venlafaxine) and was approved in January 2007. While Pristiq was approved in both the United States and Canada, the European Union declined the status, stating in part that Pristiq (marketed under the name Ellefore in Europe) "the Committee for Medicinal Products for Human Use had some concerns and was of the provisional opinion that Ellefore could not have been approved for the treatment of major depressive disorder [and] overall, the effectiveness of Ellefore had not been shown convincingly. In relation to its parent substance, Venlafaxine, Desvenlafaxine seemed to be less effective with no advantages in terms of safety and tolerability." Wyeth subsequently withdrew its application for approval.

In December 2015 Pfizer announced the results from a Phase 3 study evaluating the efficacy, safety and tolerability of Pristiq (sustained release) in pediatric patients ages 7-17 with Major Depressive Disorder. The results indicate that Pristiq were not significantly different from placebo.

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*While great care has been taken in organizing and presenting the material throughout this website, please note that it is provided for informational purposes only and should not be taken as Medical Advice.

*The statements on this website have not been evaluated by the Food and Drug Administration (FDA). The products and labels mentioned / sold are not intended to diagnose, treat, cure, or prevent any disease or illness.

* Testimonial results may vary person to person.

*The program outlined in Point of Return is not meant to substitute your doctor, instead it is to be utilized with your physician to help you with your drug withdrawal process and with his or her consent.

*Because prescription medications can cause severe withdrawal reactions, do not stop taking any medication without first consulting your physician. The decision to taper any medication should be discussed with your doctor and done with their consent and support. More...