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Zoloft In-Home Withdrawal and Tapering Program

Zoloft is the trade name for Sertraline. Zoloft is not considered a drug of abuse but it can cause both physical and psychological dependence. Zoloft is an antidepressant within the SSRI classification, meaning it exerts it action primarily on Serotonin.  Zoloft, like all antidepressants, were approved for short-term use, following studies that lasted approximately 2 months. [1 There is little data on people taking antidepressants for years and time has shown that a Zoloft Discontinuation Syndrome can occur, and can include changes in sleep patterns, an increase in anxiety or depression, gastrointestinal distress and many others. [2] Dependence to Zoloft places extreme demands on your body and nervous system. Point of Return implements slow reduction schedules and specifically designed nutraceuticals to support the body's unique needs during a Zoloft taper and reduce Zoloft withdrawal symptoms. Let our experts guide you on the correct taper rates, we have helped people in 78 countries and are here to help you too.*


    Although Zoloft is deemed non-addictive, the pharmaceutical companies that produce Zoloft do state that Zoloft can lead to dependence, tolerance and cause a withdrawal syndrome known as a Zoloft Discontinuation Syndrome.  If you have difficulty reducing your dose of Zoloft, that is an indication your nervous system has adapted to the drug.[2]  Once Zoloft dependence has occurred, its critical to follow a slow Zoloft taper to minimize the symptoms.  Many find that even with a gradual taper the Zoloft withdrawal symptoms are debilitating, which is why we implement the use of nutraceuticals to both diminish the withdrawal symptoms and assist in the healing of the receptors.* 



    Zoloft Withdrawal is a cluster of symptoms that can interfere with all aspects of life.  46% describe Zoloft Withdrawal as severe.[3]  Zoloft Withdrawal is deemed the Zoloft Discontinuation Syndrome and can include irritability, anxiety, nausea, dizziness, nightmares, prickling of the skin, insomnia and many other symptoms. Zoloft withdrawal symptoms can begin by missing one dose or even through a dose reduction. [4] Zoloft withdrawal can be minimized with the proper Zoloft taper schedule.  Our nonprofit has helped people in 78 countries, contact us for help to come off Zoloft.*





    For over 17 years, Point of Return 501(c)3 nonprofit, has helped people all over the world with safely weaning off Zoloft. Our Zoloft withdrawal program is a proven holistic approach that allows you to step down on Zoloft while minimizing Zoloft withdrawal symptoms with proven, specifically designed nutraceuticals that will not interact, yet provide needed relief.  Your Zoloft tapering program is done under the guidance of Our Team, Your Physician, and Pharmacist and allows you to taper off Zoloft in smaller reduction amounts that are not produced by the pharmaceutical companies.  Our Pre-Taper is for Zoloft symptom relief - you will not wean Zoloft until you feel better.  This is where our advanced nutraceuticals are critical to the Zoloft withdrawal process.  We understand the unique demands placed on the body and nervous system by Zoloft.  Point of Return provides healthy, proven, Drug-Free strategies to help ease Zoloft withdrawal symptoms while supporting your well being.*

    Each program is individualize based on your particular circumstance.  We email an assessment after you order the program, which allows us to uniquely customize each program and tailor specific needs.  Factors we assess are age; length of time on the Zoloft; other medications; health challenges; life stressors; drug/drug, dug/herb, drug/vitamin interactions.  No need to go through Zoloft withdrawal alone, work with our Prescription Drug Experts.*

    Follow a proper Zoloft taper with Point of Return



    • aggression
    • anxiety
    • balance issues
    • blurred vision
    • brain zaps
    • concentration impairment
    • constipation
    • crying spells
    • depersonalization
    • diarrhea
    • dizziness
    • electric shock sensations
    • fatigue
    • flatulence 
    • flu-like symptoms
    • hallucinations
    • hostility
    • highly emotional
    • indigestion
    • irritability
    • impaired speech
    • insomnia
    • jumpy nerves
    • lack of coordination
    • lethargy
    • migraine headaches / increased headaches
    • nausea
    • nervousness
    • over-reacting to situations
    • paranoia
    • repetitive thoughts or songs
    • sensory & sleep disturbances
    • severe internal restlessness (akathisia)
    • stomach cramps
    • tremors
    • tinnitus (ear ringing or buzzing)
    • tingling sensations
    • troubling thoughts
    • visual hallucinations / illusions
    • vivid dreams
    • speech issues
    • visual changes
    • worsened depression* 



     Proven Program completed In-Home with Expert Guidance 

    ✔ Slowly Wean Off Zoloft

    ✔ All-Natural Nutraceuticals to help ease symptoms and make Zoloft Withdrawal more comfortable*

    ✔ Professional information on interactions 

    ✔ Free Mentoring on our 24/7 private Discussion Board

    ✔ Free Assessment Upon Starting our Program (a $400 value)


    Enter Discount Code ADFree for FREE Ground Shipping on your Withdrawal Program (USA & Canada Only)


    It is estimated that 20% of people quitting antidepressants will experience withdrawal symptoms, but other studies suggest up to 80% of people who abruptly stop antidepressants may experience withdrawal symptoms.  Zoloft, like all antidepressants, work by altering our natural neurotransmitter production, often shunting Serotonin or Norepinephrine levels higher in the brain while starving other areas of the body. Zoloft withdrawal can be mistaken for depression and the physical complaints not identified.  A slow Zoloft taper is necessary to minimize the Zoloft withdrawal symptoms. [5] Generally the first symptoms are felt after either missing a dose or reducing a dosage.  For some the Zoloft withdrawal symptoms are severe, immediately interfering with life, and for others the symptoms are more tolerable.  If you want help to safely taper Zoloft, please contact our experts.*

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    Kathy - Zoloft taper for success getting off Zoloft

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    Today I am alive and I can hold my beautiful son in my arms because of Point of Return's help with their withdrawal program and compassion. More...

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    Stephen - Zoloft Withdrawal Symptoms Success Story

    After spending  virtually all of my adult life on antidepressants, I had often wondered if I’d ever feel as “alive” again. Well, I’m thankful to report today that I’m feeling alive again in ways I haven’t felt since before I began taking antidepressants!  More...

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    Mellie - Zoloft Withdrawal Success Story

     You didn't just give me my life back. You gave my baby girl her Mommy. My amazing husband got his wife. My mother got her daughter, my siblings got their sister back. I've been "gone" a long time, and I can't tell you how good it feels to know that I came back from that place. More...

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    How long do Zoloft Withdrawal Symptoms last with our team

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    ZOLOFT HISTORY AND INFO  ( link | pdf ) 



      By 2013 Zoloft was the most prescribed antidepressant and second most prescribed psychiatric medication (Alprazolam was first) on the United States market, with over 41 million prescriptions.  

      New research at Wake Forest Baptist Medical Center found that Zoloft significantly increased the volume of one brain region in depressed subjects but decreased the volume in two brain areas in other subjects. Both areas in the brain are critical for a wide array of functions including memory, learning, spatial navigation, will, motivation and emotion. 

      Because SSRI's influence numerous systems of the body and brain, stopping Zoloft abruptly can cause a discontinuation syndrome known as withdrawal. 60% of Zoloft patients were found to experience Zoloft withdrawal symptoms.  

      Zoloft's history dates back to the early 1970s when a scientist named Reinhard Sarges was working on a set of psychoactive compounds called tametraline for Pfizer Pharmaceutical. The initial development brought strange and unwanted side effects in animal tests but in 1977 two other scientists combined tematraline with other compounds and found a Serotonin Reuptake Inhibitor that later became Zoloft (Sertraline). 

      In 1991 Sertraline was officially approved by the FDA and in 2002, Zoloft was approved for use in children and teenagers under the age of 18 (with OCD). In 2005 the FDA added a warning label about Zoloft advising of suicidal behavior, but in 2007 the warning was revised to include young adults up to the age of 24.

      Zoloft (Sertraline) is an antidepressant in a group of drugs called Selective Serotonin Reuptake Inhibitors (SSRIs) that exerts the majority of its action on Serotonin, with minimal effects on Norepinephrine and Dopamine.   

      Compared to other SSRIs (Selective Serotonin Reuptake Inhibitors), Zoloft tends to have a higher rate of psychiatric side effects including anxiety, agitation, and insomnia. 

      Serotonin influences the cardiovascular, renal, immune and gastrointestinal systems due to its effect on the contraction of smooth muscles, and is essential to regulate body temperature, heart rate, blood pressure and the sympathetic nervous system. The alteration of Serotonin by Zoloft explains the high rate of gut and cardiovascular related side effects. Patients on Zoloft have much higher rates of sexual dysfunction versus other antidepressants due to Zoloft's effect on Serotonin, but lower rates of cognitive decline from its secondary effect on Dopamine. In pregnant women, higher rates of birth defects have been associated with Zoloft due to significant concentrations being present in fetal blood.

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      Miranda - Zoloft taper Success Story

      “ Each day that comes is filled with renewal, increased strength, and a determination to not let my story go unspoken. Thank you, Point of Return, for the great part you have played in my story of healing. I will remain forever grateful.

      —Miranda (Zoloft Withdrawal Success Story)




      Abdominal pain, agitation, anxiety, constipation, decreased sex drive, diarrhea or loose stools, difficulty with ejaculation, dizziness, dry mouth, fatigue, gas, headache, decreased appetite, increased sweating, indigestion, insomnia, nausea, nervousness, pain, rash, sleepiness, sore throat, tingling or pins and needles, tremor, vision problems, vomiting, Acne, allergic reaction, altered taste, back pain, blindness, breast development in males, breast pain or enlargement, breathing difficulties, bruise-like marks on the skin, cataracts, changeable emotions, chest pain, cold, clammy skin, conjunctivitis (pinkeye), coughing, difficulty breathing, difficulty swallowing, double vision, dry eyes, eye pain, fainting, feeling faint upon arising from a sitting or lying position, feeling of illness, female and male sexual problems, fever, fluid retention, flushing, frequent urination, hair loss, heart attack, hemorrhoids, hiccups, high blood pressure, high pressure within the eye (glaucoma), hearing problems, hot flushes, impotence, inability to stay seated, increased appetite, increased salivation, increased sex drive, inflamed nasal passages, inflammation of the penis, intolerance to light, irregular heartbeat, itching, joint pains, kidney failure, lack of coordination, lack of sensation, leg cramps, menstrual problems, low blood pressure, migraine, movement problems, muscle cramps or weakness, need to urinate during the night, nosebleed, pain upon urination, prolonged erection, purplish spots on the skin, racing heartbeat, rectal hemorrhage, respiratory infection/lung problems, ringing in the ears, rolling eyes, sensitivity to light, sinus inflammation, skin eruptions or inflammation, sleepwalking, sores on tongue, speech problems, stomach and intestinal inflammation, swelling of the face and throat, swollen wrists and ankles, thirst, throbbing heartbeat, twitching, vaginal inflammation, hemorrhage or discharge, yawning, Abnormal dreams or thoughts, aggressiveness, exaggerated feeling of well-being, depersonalization ("unreal" feeling), hallucinations, impaired concentration, memory loss, paranoia, rapid mood shifts, suicidal thoughts, teeth-grinding, worsened depression.In a few people, Zoloft may trigger the grandiose, inappropriate, out-of-control behavior called mania or the similar, but less dramatic, "hyper" state called hypomania 


      Severe: visual impairment, coma, seizures, anaphylactoid reactions, bronchospasm, ocular hypertension, suicidal ideation, SIADH, torsade de pointes, AV block, ventricular tachycardia, vasculitis, bradycardia, lupus-like symptoms, agranulocytosis, serum sickness, GI bleeding, pancytopenia, aplastic anemia, Stevens-Johnson syndrome, toxic epidermal necrolysis, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), angioedema, rhabdomyolysis, optic neuritis, pancreatitis, hepatic failure, pulmonary hypertension, renal failure (unspecified), serotonin syndrome, bone fractures, neonatal abstinence syndrome, persistent pulmonary hypertension of the newborn  

      Moderate: ejaculation dysfunction, constipation, palpitations, impotence (erectile dysfunction), melena, ataxia, euphoria, teeth grinding (bruxism), hallucinations, confusion, hypertension, sinus tachycardia, peripheral vasodilation, hypercholesterolemia, bullous rash, blurred vision, elevated hepatic enzymes, edema, hematuria, vaginal bleeding, priapism, hypothyroidism, hyperglycemia, galactorrhea, hypoglycemia, diabetes, dystonic reaction, akathisia, depression, impulse control symptoms, hostility, psychosis, mania, hyponatremia, QT prolongation, bleeding, thrombocytopenia, platelet dysfunction, leukopenia, hematoma, trismus, cataracts, hepatitis, jaundice, urinary incontinence, hyperprolactinemia, osteopenia, withdrawal withdrawal, growth inhibition


      Mild: nausea, diarrhea, insomnia, xerostomia, dizziness, fatigue, drowsiness, tremor, dyspepsia, agitation, hyperhidrosis, libido decrease, vomiting, appetite stimulation, lethargy, hypoesthesia, hyperactivity, syncope, irritability, purpura, epistaxis, maculopapular rash, alopecia, pruritus, urticaria, muscle cramps, arthralgia, tinnitus, mydriasis, yawning, fever, orgasm dysfunction, hyperkinesis, headache, nightmares, anxiet, petechiae, ecchymosis, photosensitivity, malaise, nocturia, gynecomastia, menstrual irregularity, weight loss


      Children, growth inhibition, suicidal ideation

      The safety and efficacy of sertraline have been established in the treatment of obsessive compulsive disorder in children and adolescents 6 to 17 years of age. Two placebo-controlled trials were conducted in pediatric patients with major depression, but the data were not sufficient to support an indication for use. There is a causal relationship between the use of antidepressants, such as sertraline, and the risk of suicidal ideation and behavior in children, adolescents, and young adults (ages 18 to 24 years). Pooled analysis of 24 placebo-controlled trials (n = 4,400) lasting up to 16 weeks in pediatric patients with major depressive disorder (MDD), obsessive compulsive disorder (OCD), or other psychiatric disorders showed a greater risk of suicidality during the first few months of treatment in those receiving antidepressants (SSRIs and others). The average risk of such events on drug was 4% and 2% for placebo; however, no suicides occurred in these trials. Risk for suicidality does not appear to differ among individual antidepressant agents. However, data from a cohort of 36,842 children (age range: 6 to 18 years) suggested those who use multiple antidepressants may have a higher risk of suicide behavior, most likely a result of increased severity of depression rather than drug effect. Suicidal ideation appears to be more prevalent in children with or at high risk for bipolar affective disorder on antidepressants. In a study of 52 patients (mean age: 15 years; range: 7 to 22 years) with bipolar affective disorder or subthreshold manic symptoms, 25.5% had new onset suicidal ideation within the first 3 months of antidepressant use. The clinical need for an antidepressant in children or young adults for any use must be weighed against the risk of increased suicidality; patients who are started on therapy should be observed closely for clinical worsening, suicidality, or unusual changes in behavior, particularly within the first few months of starting therapy or after dose changes. It is unknown if the suicidality risk extends to longer-term therapy (i.e., beyond several months). The possibility of a suicide attempt is inherent in patients with primary depressive symptoms or symptoms secondary to another primary disorder such as OCD. All patients with a history of suicidal ideation or behaviors prior to treatment are considered at an increased risk for suicidal ideation or attempts, and should be closely monitored during treatment with sertraline. In patients who exhibit a worsening of depression or emerging suicidality, a decision should be made to change or discontinue treatment. If discontinuing, the medication should be tapered as rapidly as possible, but with recognition that abrupt discontinuation can also cause adverse symptoms. All antidepressants should be prescribed in the smallest quantity consistent with good patient management in order to reduce the risk of overdose. Data are inadequate to determine whether the chronic use of SSRIs causes long-term growth inhibition; however, decreased appetite and weight loss have been observed with the use of SSRIs. Monitor for potential growth inhibition (e.g., weight and height) in pediatric patients treated with an SSRI.   


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      According to the FDA 

      Discontinuation of Treatment with Zoloft 

      Symptoms associated with discontinuation of ZOLOFT and other SSRIs and SNRIs, have been reported (see PRECAUTIONS). Patients should be monitored for these symptoms when discontinuing treatment. A gradual reduction in the dose rather than abrupt cessation is recommended whenever possible. If intolerable symptoms occur following a decrease in the dose or upon discontinuation of treatment, then resuming the previously prescribed dose may be considered. Subsequently, the physician may continue decreasing the dose but at a more gradual rate. 


      Inform pregnant women that ZOLOFT may cause withdrawal symptoms in the newborn or persistent pulmonary hypertension of the newborn. Talk to your healthcare provider about the benefits and risks of taking ZOLOFT during pregnancy.


      *While great care has been taken in organizing and presenting the material throughout this website, please note that it is provided for informational purposes only and should not be taken as Medical Advice. 

      *The statements/info on this website have not been evaluated by the Food and Drug Administration (FDA). The products and labels mentioned / sold are not intended to diagnose, treat, cure, or prevent any disease or illness. 

      *The program outlined in Point of Return is not meant to substitute your doctor, instead it is to be utilized with Your physician to help you with your drug withdrawal process and with his or her consent throughout. 

      *This program is not meant to cure or prevent any disease or illness. 

      *Because prescription medications can cause severe withdrawal reactions, do not stop taking any medication without first consulting your physician. The decision to taper any medication should be discussed with your doctor and done with their consent and support throughout the process. More..